Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results
نویسندگان
چکیده
AIM To report long term oncologic outcomes after adjuvant radiotherapy (RT) for stage I seminoma. METHOD We reviewed the complete data set for all patients treated at our institute between 1988 and 2005 for stage I seminoma with adjuvant RT after radical orchiectomy . RESULTS A total of 85 patients were included. The median follow-up was 15 years. The 20-year overall survival (OS) and relapse free survival (RFS) were 92% and 96.3%, respectively. No severe acute and late complications were recorded. Overall 5.9% of patients had a second unrelated malignancy. CONCLUSION Adjuvant RT is an efficacious and safe treatment in stage I seminoma.
منابع مشابه
Stage I seminoma: adjuvant treatment is effective but is it necessary?
Over the past 40 years, the incidence of testicular cancer has increased in almost all populations worldwide, and it remains the most common solid malignancy in young men between the ages of 20 and 35 years. Primary germ cell tumors are the predominant histological type, with approximately 60% of germ cell tumors being pure seminoma, 30% being nonseminomatous germ cell tumors, and 10% being mix...
متن کاملCost analysis of adjuvant management strategies in early stage (stage I) testicular seminoma
BACKGROUND Acceptable post-orchiectomy adjuvant therapy strategies for stage I seminoma patients include surveillance, para-aortic radiation therapy (RT), dog-leg RT, and a single cycle of carboplatin. The required follow-up recommendations were amended by the National Comprehensive Cancer Network (NCCN) in 2012. Given a cause-specific survival of nearly 100%, a closer analysis of the reimburse...
متن کاملTreatment of stage I seminoma: 25 years of experience
AIM OF THE STUDY To review management and outcomes in patients with stage I seminoma after orchidectomy. MATERIAL AND METHODS Between 1979 and 2004 a total 292 patients with stage I seminoma were treated with adjuvant chemotherapy or radiotherapy or were placed on surveillance. Median age at diagnosis was 36 years (range 20-69), with median follow-up 76.5 months (range 11-294). Of the patient...
متن کاملTherapeutic options following orchiectomy for stage I seminoma.
Stage I seminoma represents the paradigm of a curable malignancy, with survival of 100% an expected outcome no matter what treatment option is chosen. However, consensus has not been reached among urologists and oncologists regarding the optimal postoperative management in men with clinical stage I testicular seminoma. Currently, men are offered active surveillance, adjuvant radiation therapy, ...
متن کاملChoosing Treatment for Stage I Seminoma: Who Should Get What?
Lawrentschuk and Fleshner accurately depict the difficulty in choosing among observation, prophylactic radiation, and adjuvant chemotherapy for clinical stage I testicular seminoma. The physican has competing priorities of avoiding unnecessary treatment while minimizing the overall burden of both therapy and surveillance testing. The patient has to contend with defined risks that exist with any...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016